Prediction of Thrombus Formation on Shear Flows by CFD Methods with Considering Transport of Concentration and Aggregation Process

Abstract

This investigation describes the hybrid method to combine concentration transport process of species by FDM and platelet aggregation by DPD. Computational objects are 5 types of pipe flows through an orifice, which were same geometries in our previous observation experiments of thrombus formation. Using the velocities and pressures in case of turbulent flow by N.S. Equations, the concentrations of species with chemical reaction are computed by FDM. In our newly proposed hybrid model, DPD is applied to express the aggregation process of platelet on the wall. By adding the DPD model with aggregation, number of aggregated and activated platelets was evaluated. By using probability of deposed platelets on the wall, the total number history of activated and aggregated platelets was obtained. The rate of aggregated platelets was compared with our previous experiments of thrombus formation rate.