This article is a very basic introduction to writing a scientific paper, which follows on from “Editors-in-Chief roundtable discussion:Towards improving quality of journal papers.” This article explains important issues to improve the quality of scientific papers. In particular, it focuses on the points that will make your manuscript clearer and more effective. After discussing the perspective of peer review, it provides practical advices on how to choose the title of your manuscript and how to write its abstract, introduction, methods, results, discussion, and conclusion. The article also briefly describes considerations on drawing figures and making tables and choosing their captions. It also discusses impacts of the authors’ previous research on the originality of the current manuscript, multiple submissions, and the copyright of figures and tables in previous papers. It also emphasizes the importance of polishing your manuscript before submission. Finally, it briefly advises on how to respond to reviewers’ comments.