Recently, attention has been drawn to working women. It is expected that women will be active in society such as promoting women to managerial positions and increasing number of female lecturers at various meetings. In such societal movements, various systems such as nursing cares for children and seniors have been improved, so that life events of the female can be compatible with work. However, the working women still cannot get enough understanding or encounter painful situations. Ladies' Association of The Japan Society of Mechanical Engineers (LAJ) is actively aiming to spread the Meka Jo network that can provide opportunities to talk, dissipate stress, and sometimes find solutions. In this talk, I will introduce various activities of LAJ and Support office for Female Researchers in Hokkaido University. I will also introduce my research of Origami engineering for medical devices and regeneration medicines.