Optimization of reactive oxygen species production in anti-infection system utilizing sonocatalysis

Abstract

In order to solve the problem of infection at the exit of the catheter, a anti-infective system that the irradiates ultrasound to titanium dioxide (TiO₂) particles bonded on the cuff and produces the reactive oxygen species (ROS), has been studied (Tominaga et al., 2019). In this study, conditions for maximizing ROS production while ensuring safety during percutaneous ultrasonic irradiation were investigated. By using a planar transducer (500 kHz, 45 mm), continuous wave of ultrasound was irradiated to a suspension consisting of diluted methylene blue (MB) solution and TiO₂ particles. The ROS production was evaluated by the absorbance of the MB solution and the safety was evaluated by the temperature rise on the transducer surface. As the result, as the above conditions, the ultrasound intensity of 1 W, the TiO₂ particles of 10 mg, and the total irradiation time of 15 minutes were determined.