Needs and issues of in silico in developing medical devices for cardiac electrophysiology

Abstract

Although computer simulation (in silico) has been used as a method of theoretical study, it has recently been employed in medical device development.(1) At a development stage. By performing simulations of electrical defibrillation, appropriate shock waveform, electrode, etc. were found for the development of intra-cardiac defibrillator.(2) As a medical device itself. A simulator for cardiac safety pharmacology tests. Changes in action potentials and clinical electrocardiograms, and presence of arrhythmogenicity of unknown drugs can be simulated.(3) As a part of medical devise. Based on the intra-atrial electrograms together with a simulator that complements the electrophysiologic properties, realtime visualization of clinical atrial fibrillation was achieved.To resolve the technical, economic, and ethical limitations of medical devices, in silico was come to be utilized in various ways. More recently, in silico has been sought after as an explanation tool for the AI black box, and thus further expansion is expected.