Drug Determined Reachability: Modeling and Analysis of Multiple Drug Infusions for Acute Heart Failure Treatment

抄録

Appropriate pharmacological intervention in the setting of acute heart failure (AHF) presents unique challenges for each patient. Early identification of patients who will not respond to pharmacological therapy alone would be crucial in the clinician窶冱 decision to provide additional therapy such as mechanical support. This paper proposes the concept of drug determined reachability, the maximum range that multiple drug infusions can span cardiovascular parameters. Our approach models how multiple drug infusion affects key cardiovascular parameters, while considering dosage limitations, multi-dependencies of multiple drugs, and nonlinear interaction of drugs to the gradient of the Frank-Starling Curve. The simulation of drug determined reachability sheds light on the effectiveness or limitation of closed-loop therapeutic systems for acute heart failure treatment depending on each patient窶冱 pathophysiological scenario.