Renal Hemodynamics Modeling for Cardiovascular Simulator

抄録

The kidneys play a fundamental role in the cardiovascular system to regulate blood pressure by maintaining body fluid and electrolyte balance. Renal function is strongly associated with cardiovascular disease, such as heart failure and hypertension. The aim of this study was to develop a comprehensive cardiovascular model capable of describing the effects of angiotensin II (ANGII) and its type 1 receptor blocker telmisartan (TELM) on renal hemodynamics. We employed a lumped parameter model to simulate systemic and renal hemodynamics, where the resistances were influenced by ANGII and TELM. Additionally, we adopted a variable resistance for the renal afferent arteriole, allowing it to respond to pressure variations. This effectively simulated the autoregulatory function that maintains renal blood flow and glomerular pressure relatively constant against changes in systemic arterial pressure. After parameter adjustments, the model successfully reproduced renal blood flow waveforms. Furthermore, the effects of ANGII and TELM on renal blood flow and urine excretion were simulated with reasonable accuracy.