心室の可変容量模型の駆動エネルギーと心臓酸素消費量との相関

抄録

Correlation was studied between the driving energy of a time-varying capacitance model of the left ventricle and cardiac oxygen consumption. The model is known to simulate ventricular pressure-volume dynamics. When the model changes its capacitance from a diastolic to an end-systolic level while ejecting volume against pressure load, it requires energy supply (driving energy) equal to the sum of its external work and the increment in the potential energy. This potential energy increment corresponds theoretically to the specific area in the pressure-volume diagram that is bounded by the end-diastolic and end-systolic curves and the pressure-volume trajectory during isovolumic relaxation. Using data, found in literature and also obtained in my own experiments, I found a close correlation between the ventricular pressure-volume area corresponding to the driving energy and the oxygen consumption in the real heart. The specific pressure-volume area, which can be measured simply by planimetry, seems to be a promising candidate for the practically useful predictor of cardiac oxygen consumption.