抄録
We have developed a novel three-dimensional microfabrication method for biodegradable materials. Unlike conventional processes, our process satisfies high-resolution and high-speed requirements. The system design allows the processing of micro-level forms by stacking up melted polymers from the nozzle. We adopted a batch process to supply materials in order to eliminate the prior process that employed toxic solvents. In addition, it is possible to handle almost all biodegradable thermoplastic resins by adopting this system. A single layer from the piled-up layers of extruded lines can be observed using SEM images to evaluate the resolution. The lateral and depth resolutions attained are 70μm and 40μm, respectively. Poly (lactide) (PLA) enables millimeter-sized structures such as micro-pipes, micro-bends, and micro-coil springs to be processed in less than 10min. The biocompatibility of the newly fabricated device was evaluated using a cell line (PC 12). For this purpose, a small vessel with a transparent base was fabricated and the cells cultivated in it. The results were then compared with the results obtained using the standard method. Our system renders it possible to produce toxic-free, as well as transparent and leakage-free devices. The shape of the structures can be easily changed and quickly modified. Our system is expected to have potential applications in optimum design and fabrication of implantable devices.
