抄録
Relative decrease in the blood donor population caused by a rapidly declining birthrate and aging society has brought on a chronic shortage of preserved blood. Taking countermeasures against these problems, various types of hemoglobin based oxygen carriers (HBOCs) are under investigation. Among them, the development of the hemoglobin vesicles (HbV) is being vigorously promoted in Japan and has been recognized as a useful alternative for red blood cell (RBC). HbV encapsulate concentrated Hb solution in phospholipid vesicles, and measures approximately 200-250 nm in diameter, which is roughly 1/30 size of a human RBC. Therefore, HbV will easily transport oxygen through a narrowed microvessel whose diameter is smaller than RBC. In addition, flexible adjustment of HbV performance parameter permit effective transport of oxygen to ischemic region. However, it is difficult to determine experimentally the effective performance parameter according to the various circulatory disease. Based on these backgrounds, in this study, we constructed numerical model to investigate the oxygen delivery process of HbV in microvessel including RBC. The final aim of this study is to design numerically effective HbV for various circulatory disease.
