抄録
It is believed that mechanical stimuli such as stretch deformation of extracellular matrix is transmitted into the cell via focal adhesion complex and actin cytoskeleton. In osteoblasts and vascular endothelial cells, thick actin stress fibers form aligned network structure. We expect that intracellular strain distribution transmitted from outside is affected by such heterogeneous cytoskeletal structure. In this study, we observed cellular morphological dynamics during stretch application by using cell stretching microdevice. We succeed to obtain time lapse images of stretched cell, and tried to measure the distribution of intracellular strain during stretch application by using digital image correlation method.
