バイオエンジニアリング講演会講演論文集
Online ISSN : 2424-2829
セッションID: 2H31
会議情報
2H31 カテプシンK蛍光染色による剛性の異なるPCLおよびHAp/PCL基質上で培養した破骨細胞の代謝挙動の評価
田中 基嗣飛石 好輝松波 純希金原 勲
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会議録・要旨集 認証あり

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The main purpose of this study is the clarification of the effect of substrate elastic modulus on the metabolic behavior of osteoclasts on PCL substrates, and investigation of osteoclastic behavior of HAp/PCL substrates, aiming to extend the possibility to design the substrate elastic modulus. Here, PCL substrates with different elastic modulus were prepared by changing cooling method. The evaluated elastic modulus was 0.295 [GPa], 0.406 [GPa] and 0.657 [GPa] for rapid cooled, slow cooled and furnace cooled PCL substrates, respectively. HAp/PCL substrate with elastic modulus of 0.461 [GPa] was also prepared by rapid cooling. As results, the ratio of activated osteoclasts secreting cathepsin K increased with increasing elastic modulus of PCL substrates. In addition, it was suggested that osteoclasts can produce acid even on HAp/PCL substrates. It is expected that the effect of the composition with HAp on the osteoclastic metabolic behavior will be investigate parametrically, in future.
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