In designing the high head pump turbine runner, the vibratory stress caused by the interaction force between the guide vane and the runner vane should be exactly predicted. This paper, first, presents the analysis method to calculate the vibratory stress of the tuned runner by the cyclic symmetry method. And the simple procedure to estimate the vibration response of the mistuned runner is also proposed. Secondly, the response analysis of the actual runner is carried out, and some calculated results are shown to explain the typical vibration characteristics of the tuned and mistuned runner. Lastly, the measured and calculated vibratory stresses of the actual runner are compared to verify the validity of the proposed method.