This paper proposes a multidisciplinary design optimization approach of smart structures for vibration and sound suppression. The smart structure consists of panel with one fixed end, two piezoelectric actuators and control system. The control system is designed according to the H2 specification with a reduced-order modal model derived from FEM and modal analysis. The sound pressure level of sound radiation from the vibrating panel is calculated by BEM. The design problem for improving the H2 performance is defined, and then the piezoelectric actuators and the control system are simultaneously optimized by the presented approach, resulting in an enhanced performance for the vibration and sound suppression.