Abstract
Neutrophil is known as one of the immunological system, and it has chemotaxis by concentration gradient of cytokine. In general, the neutrophil is moved to high concentration of cytokine in the blood vessel, and derived to the inflammation areas. However, the mechanism of propulsion has not been elucidated yet. By understanding this mechanism, it can be applied to medical technologies such as drug delivery systems and micro machines. Therefore, it is necessary to elucidate the principle of neutrophil's propulsion. In our previous investigation, it was found that concentration gradient on the surface of neutrophil is reverse toward surrounding fluid. In this paper, concentration on the surface of neutrophil and surrounding fluid are examined computationally by concentration gradient of cytokine. From the computational result, the reverse concentration gradient occurs by increasing diffusivity of cytokine or adsorption/desorption coefficient. It is concluded that the fluidity of neutrophil surface influences neutrophil's motion.
