低コヒーレンス干渉計を用いた微小循環血流速分布マイクロ断層可視化法の評価

抄録

Rheological behavior of interstitial fluid in epidermal tissue, including blood micro-circulation, can vary skin mechanics in micro scale, i.e. visco-elasticity. Therefore, an in vivo diagnosis of blood velocity is quite necessary to diagnose skin tissue. In this paper, we propose OCDV (Optical Coherence Doppler Velocigraphy), which is a method of tomographic micro-visualizing blood flow velocity based on a high frequency modulated low coherence interferometer. The rapid scanning optical delay line was implemented as a reference arm so as to visualize video-rate tomography of velocity field. This system applied experimentally to RBCs suspension (Hct40%) pressurized into a simplified capillary vessel of rectangular PDMS microchannel. Consequently, this could offer tomographic velocity in micro circulation, as an in vivo tomographic diagnosing tool of blood flow velocity profiles in tissue.