体外摘出肝臓灌流における臓器の酸素動態と流動特性

抄録

The machine perfusion (MP) techniques have extensively studied to preserve and resuscitate donated organ for organ transplantation. The MP technique is able to not only supply the organ with nutrition and oxygen continually through the preservation solution but also evaluate the liver viability. However, the perfusion machine that can evaluate liver viability is not yet established. In this study, the evaluation index was suggested by correlation between oxygen consumption dynamics and the liver function using porcine donated livers. As a result, the liver, which have oxygen consumption gradient of the low level was higher hepatic artery pressure and aspartate amino transferase of effluent enzyme. Therefore, oxygen dynamics of the liver during machine perfusion associated with the liver function and can used for the organ evaluation index before implantation.