循環流路内における血栓形成の電気的計測およびシミュレーションによる評価

抄録

Connector gap, a gap between connector and tube, is where very easily to occur thrombus formation in extracorporeal blood circulating system. The aim of this study is to develop a system to detect thrombus formed at the connector gap in an extracorporeal blood circulating system and evaluate it. In the experiment, the blood circulating system incorporating the connector electrode was filled with fresh porcine blood, and calcium chloride was added to promote thrombus formation. Also, the experimental condition was modeled by simulation, the frequency response was obtained, and it was evaluated compared with the experimental results. In both the experiment and the simulation, the permittivity greatly increased at low frequencies, and the rate of increase of the permittivity showed the minimum value at about 10 MHz because of thrombus formation. The feasibility of the connector electrode and the usefulness of the simulation were shown.