抄録
This study aims at forming a fluorescent complex between HAp coatings and amino acid ligands by using CIP process in order to suppress cytotoxicity of conventional fluorescent HAp complex and also enhance antibacterial properties by visible light irradiation. Three amino acids, phenylalanine, tryptophan and tyrosine were successfully fabricated by applying pressures 800 MPa for 1.2 ks. Fluorescence by complex of HAp with three amino acids was observed by UV irradiations. Cytotoxicity assessments were conducted by using MC3T3-E1 osteoblast cells. Observing optical density of mediums after cultivations revealed no significant differences among five groups in the same culture periods. The results demonstrated that biocompatibility of HAp/amino acid complex was similar to HAp itself. The reduction of bacterial growth rate was observed in antibacterial evaluation after irradiating visible light. The fluorescent complex HAp/ photocatalyst coating showed significant reducing of bacterial growth rate comparing with the cases by non-fluorescent HAp coating.
