マイクロチャンバーアレイを備えた細胞伸展マイクロデバイスの開発

抄録

In a conventional cell stretching device, it was difficult to observe the initial and in-situ cellular response to stretching. Our group has also been focusing on the development of stretching device to address problems. Although we could measure a cell response by using previous device, the measurement efficiently was not high because it had only 6 culture chambers for measurement. This paper presents a novel cell stretching micro device having micro chamber array for in-situ observation of stretched cell. The presented device consists of elastic micro chambers and SU-8 blocks. The device was fabricated by conventional photolithography. This device has 134 micro chambers, which enable to observe cell response to stretching in the real time. It was demonstrated that the fabricated device could be used to observe in-situ cell responses to stretching.