This paper describes high-cycle fatigue characteristics of quasi-isotropic CFRP laminates [-45/0/45/90]_s to 10^8 cycles. To investigate the fatigue behavior in the high-life region, the fatigue tests were conducted with frequency of 100Hz since it's difficult to conduct its with 5Hz and the damage behavior of the specimen was observed with a microscope, a soft X-ray photography and a 3D ultrasonic inspection system. In this study, to evaluate quantitive characteristics of transverse crack propagation in the high-cycle region, the energy release rate associated with transverse crack growth to the width direction was calculated and the transverse crack growth to the width direction was evaluated based on a modified Paris-law approach.