小型ロボットアームの画像認識機能を用いたロバストな自動培地交換システムの開発

抄録

This study explores the diverse factors contributing to the variability in reproducibility within life science research. Recognizing the potential impact of environmental and human factors, we focused on introducing laboratory automation. We designed an innovative automatic media exchange system employing a compact, multi-functional robotic arm equipped with image recognition capabilities for precise target object localization. The core enhancement involved the integration of an optimized 3D-printed hand into the robotic arm, facilitating seamless plate manipulation and pipette transport and eliminating the need for manual intervention. Furthermore, complementary peripheral devices such as tailored work stages and chip disposal stands were developed to streamline the exchange of culture media. Invalidating the efficacy of our automated media exchange system, we achieved a notable waste liquid removal rate exceeding 97%. Comparative trials with human operators demonstrated the system's exceptional consistency in executing complex exchange procedures, surpassing or achieving parity with human performance benchmarks.