抄録
Liposomes produced from lipids have been studied as promising materials for a drug delivery system (DDS), since the liposomes are relatively non-toxic and biodegradable. For using liposomes as a drug carrier, the size of liposomes and the homogeneity in their structure are the most important characteristics. In this study, a novel technique of liposome production using a gas/liquid interface in a T-shape micro-duct has been suggested. By this method, the liposomes can be obtained without harmful organic solvents and the miniaturization of liposome production can be realized. The behaviors of gas columns and liquid columns in the micro-duct were changed depending on flow rate. Diameters of the liposomes were decreased by increase of the flow rate. The diameters of liposomes seemed to be affected by the length of liquid columns. Thus, flow characteristics in a liquid column were also analyzed.
