バイオマテリアル表面の濡れ性と細胞接着性に関する評価手法の検討

抄録

In biomedical and bioengineering fields, it is important to evaluate surface information such as the surface composition, morphology and structure of biomaterials for realization of the best cell engraftment between an implanted biomaterial and a cell. Wetting phenomena are an important indicator in evaluating a solid's surface properties. However, at the present time, there are no adequate and reasonable methods to evaluate the solid surface property for the cell engraftment from a viewpoint of wetting phenomenon. In the present study, the wetting behavior of droplets on solid biomaterials is experimentally observed. Then, osteoblast cells are cultivated on the solid biomaterials to measure the amount of the cells adhering to the solid surfaces. The results are evaluated on the basis of a new wettability model that considers the adhesion energy in the horizontal and vertical directions in addition to the gravitational potential of the droplet. Then, the possibility of a surface evaluation method based on the new wettability model is considered.