In order to clarify laminar drag reduction and the slip velocity on a hydrophobic surface, the pressure loss of a rectangular duct was measured applying the six kinds of the wall surface qualities to duct inner wall. Test wall surfaces were the hydrophobic or the hydrophilic micro V-groove surface, rectangle micro groove surface and smooth surface. In the case of hydrophilic surface, a drop of water was remarkably extended by the effect of the surface ruggedness, and hydrophilicity was emphasized. On the contrary, in the hydrophobic surface, the water droplet became more spherical by the surface ruggedness, and the hydrophobicity was emphasized. From the result of the pressure loss measurement, it was clarified that the drag reduction was not occurred in all test surfaces.