The prediction of a foaming flow process is difficult because temperature, density, and thermal conductivity of polyurethane resin are changed greatly caused by heat generation resulting from the two-liquid mixture of polyol and polyisocyanate. Therefore, simulating the precise behavior of polyurethane foaming flow is very effective for reducing the development period and production costs. In this study, reaction of heat generation, density, thermal conductivity for polyurethane resin is formularized by experimental results. A foaming flow simulation was then developed by applying these formulas in the foaming flow process of polyurethane resin to a 3D flow simulation program. The following results are obtained by having compared analysis value with an experiment value. (1) Resin temperature can be calculated with precision less than error ±10℃ even if wall thickness and mold temperature are changed. (2) Specific volume can be calculated with precision of error ±8% even if wall thickness and mold temperature are changed.