抄録
Molecular dynamics (MD) simulations of molecular delivery into a lipid bilayer utilizing shock-wave-based techniques were carried out for 5Fuluorouracil (5FU). Although water penetration into the bilayer hydrophobic region was observed for a shock wave impulse range of 9.5〜57mPa.s, 5FU penetration was not observed. Therefore larger structural changes (e.g. water pore formation) than those observed in current simulations are thought to be required for 5FU penetration.
