抄録
Malaria is one of the most serious diseases for all around the world. It is thought that severe symptoms are caused by microvasucular occlusions of parasitized red blood cells (PRBC) that have adhesive property and low deformability. However, the detailed mechanisms of the vascular occlusion caused by red blood cells are still not clear. In this study, the malaria-infected blood is modeled by particles. The adhesive property of PRBC is expressed by local spring. The result shows that the PRBC interacts with some healthy RBCs and move downstream keeping attachment to the vessel wall. This phenomenon induces the high resistance to the flow, which is likely to lead to microvascular obstruction in lower shear flow.
