Non-metallic bone plate was proposed for promoting healing of fracture. The alternative materials were a natural polyetheretherketone (PEEK) and a carbon reinforced PEEK, those Young's modulus were extremely lower than that of a titanium alloy. After cyclic mechanical compression testing, an average deformation with bending motions of the titanium alloy plate was equal to that of the natural PEEK plate. The FEM analysis showed that compressive strain was occurred in the natural PEEK plate in the direction of the long axis. These two results suggested that relative movements between two broken bone surfaces might be reduced and that appropriate compression loading might be applied to the bone surfaces. These conditions may promote the healing of fracture, and the natural PEEK bone plate will be a next generation of implant for osteosynthesis.