Abstract
In the field of regenerative medicine, tissue engineering has gotten a lot of attention. Especially in the department of vascular regeneration, biodegradable vascular constructions play an important role for the regeneration of blood vessel. In this work, we propose a multi-layered vascular scaffold with porosity -gradient and stiffness-gradient in radial direction. Higher porosity at inner layer will help HUVECs to be attached while lower porosity at outer layer supports the mechanical strength of the scaffold. Multi - layered biodegradable tube with gradient porosity will be a good tool to investigate the speed of degradation after implantation. It also proposes that it will be able to avoid the possibility of intimal thickening or lack of endothelial cells.
