Abstract
Herein we propose a novel signal encoded 3-D cell culturing scaffold formed of "Surface-functionalized nano-fibrous microcapsules." The proposed scaffold not only provides anchorage for seeded cells but also aims to realize spatial guidance of cell growth and differentiation through chemical release. To demonstrate the feasibility of concept, biodegradable nano-fibrous microcapsules were successfully surface-functionalized with a chemical fluorophore. Next, the surface-functionalized microcapsules were patterned to form a spatially organized scaffold. The results show great potential as a drug releasing scaffold targeted to realize the regeneration of complex functional tissues.
