Abstract
In recent years, there is a demand to measure the actual state of bio-cells in the field of bio-medical science.As we know, there are severalmethods to observemechanical or viscoelastic characteristics of cellsthrough the microscopic visual observation. Therefore, we propose a method to measure the mechanical characteristics of bio-material, especially by using vibration of piezo driven micro tuning fork. In our device, there is a tiny needle adhered to the end of the tuning fork. We can vibrate this tuning fork at its resonance frequency and the precise mechanically driven platform can lift up the sample so that it can touch the vibration needle. Whit different contact conditions, small changes of the amplitude and the phase shift of the micro vibration can be measured. Thus we can get the mechanical characteristics of the sample and then estimate the health condition of bio-cells in term of the mechanical properties.
