The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)
Online ISSN : 2424-3124
2014
Session ID : 3P2-G05
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3P2-G05 MEMS device for cell dispersion towards screening of anti-cancer drugs(Nano/Micro Fluid System)
Maho KAMINAGATadashi ISHIDATetsuya KADONOSONOShinae KONDOHToru OMATA
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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract
Cancer is the top leading cause of death in Japan. Anti-cancer drugs are one of the most popular treatments whereas they often have heavy side effects. Anti-cancer drugs with light or no side effects are under development using tumor specific binding peptides as guides to cancer cells. However, the number of candidate peptides for the tumor specific binding peptides are extremely large. An efficient peptide screening method is necessary to find them. For this purpose, we are developing a microfluidic device to uniformly disperse cancer cells into its micro chamber and screen the peptide form the large number of peptides. In this paper, we could uniformly disperse N87 cells into the micro chamber using a micro pillar array, and selectively trap yeasts with tumor specific binding peptides by N87 cells in the micro chamber.
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© 2014 The Japan Society of Mechanical Engineers
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