インプラント型人工腎臓のためのチタン製マイクロ流路のin vivo血栓形成評価

抄録

We have been developing the implantable artificial kidney to improve quality of life of the renal disease patient. This system cleans the blood by hemofiltrating the waste molecules and extra water without dialysis fluids. In pervious study, dialysis performance was confirmed through in vivo experiment for 5 hours using rat under anesthesia. Experiments using rats under anesthesia are limited to 5 h due to overdose of the anesthesia. Long-term experiments to assess the dialysis performance and biocompatibility is mandatory. In this study, we fabricated the implant device which has microfluidic channel composed of titanium channel and dialysis membrane to evaluate biofouling on the flow pass. And we established a new in vivo long-term experiment method using rats. In vitro and in vivo experiment for 24 hours revealed titanium channel is superior to stainless channel.