Host: The Japan Society of Mechanical Engineers
Name : [in Japanese]
Date : June 02, 2018 - June 05, 2018
Tumor specific binding peptides have the potential to alleviate the side effects of anti-cancer drugs. To reduce the laborious effort for peptide screening, some microfluidic devices were proposed using adherent cancer cells or protein coated beads as the targets of peptides. We have developed a microfluidic peptide screening device with a group of cancer cell spheroids as the targets of peptides, which are closer to in vivo tumors. Channels are designed based on the fluid behavior to trap minute micro scale spheroids in the chambers of the device. The experiment results demonstrate that the fluid behaves as designed and the device can successfully form a group of spheroids.
