振動誘起流れを利用した細胞スフェロイド作製法の検討

抄録

Today, cell spheroid is receiving attention in the field of medical science and drug discovery. In this study, we propose fabrication method of cell spheroids based on vibration-induced flow. The proposed method enables to easily collect fabricated spheroids and mass production of cell spheroids. In this study, we fabricated microfluidic chip with circular pattern of micropillar array. By applying circular vibration to the chip, we succeeded in condensation of microbeads whose diameter is 10 μm instead of cells by using proposed method. The proposed method has potential of mass production of cell spheroids.