培養皿に接着した細胞に加わる音響放射力の定量化

抄録

Cell culture technology is a fundamental technology of biotechnology. In adherent cell culture, cell detachment from culture vessel is an essential process. Although enzyme-based cell detachment is the widely accepted technique, it damages cells. Nowadays, cell detachment technique utilizing ultrasound has been proposed. When ultrasound vibration is applied to the bottom of a culture dish, the acoustic radiation force is given to cells, resulting in cell detachment. For the implementation of cell detachment, the acoustic radiation force on cells should be quantified. Therefore, we developed the device to quantify the acoustic radiation force applied to the cells adhered to a culture dish.