分子ロボット作製を目的とするマイクロピペット吸引法を適用したリポソームの機械的特性評価

抄録

In this report, we evaluated the mechanical properties of liposomes by the micropipette aspiration method for the development of molecular robots. We prepared liposomes with the W/O emulsion method and aspirated them on the micropipette using negative pressure generated by the difference of the water head. We measured the deformation length of a liposome which was aspirated in the micropipette with the microscopic image. The deformation was applied to the viscoelastic model. In the result, we derived Young’s modulus (E₀ = 416 Pa and E_∞ = 57.3 Pa) and viscosity (μ = 120.4 Ns/μm). These parameters were smaller than these of cells. We considered that the result was due to the lack of cytoskeleton which keeps the form of cells of the living things. In the future, we will try to measure more liposomes and derive more accurate parameters.