This paper presents numerical results on heat transfer characteristics of turbulent gaseous flow in a micro-tube with constant wall temperature. The numerical methodology was based on Arbitrary-Lagrangian-Eulerinan (ALE) method to solve compressible momentum and energy equations. The Lam-Bremhorst Low-Reynolds number turbulence model was employed to evaluate eddy viscosity coefficient and turbulence energy. The tube diameter ranges from 100 μm to 400 μm. The aspect ratio of the tube diameter and the length (L/D) is fixed at 200. The obtained Reynolds number ranges widely up to 10081 and the Mach number at the outlet ranges from 0.1 to 0.9. The heat transfer rates obtained by the present study are higher than those of the incompressible flow. This is due to the additional heat transfer near the micro-tube outlet caused by the energy conversion into kinetic energy.