Host: The Japan Society of Mechanical Engineers
Name : [in Japanese]
Date : October 08, 2022 - October 09, 2022
Nanopores on two-dimensional (2D) materials have recently attracted growing interest in biosensing due to the atomic thickness, close to the gap between nucleotides. Consequently, they have become a suitable candidate to improve molecule sensing resolution, having huge potential to characterize the structure of DNA molecules for precision medicine and DNA vaccine development. To acquire precise genetic information from DNA molecules, getting precise ionic current in nanopore is essential. The ionic current of nanopore is related to the conductance of the electrolyte, geometrical features of nanopore, and the external applied bias. On the other hand, decreasing the size of nanopore can slow down migration speed of DNA and thus enhancing temporal resolution of DNA sequencing. Albeit the merits of small nanopore, ion transport through nanopores on 2D materials is poorly understood so far due to challenging fabrication processes, especially as the pore diameters are comparable to the single stranded DNA size. Therefore, the objectives of this work are to (i) experimentally investigate ionic current behavior in sub-10 nm pores on monolayer molybdenum disulfide (MoS2) and (ii) improve the understanding of ionic current blockage variation due to DNA translocation through nanopores. On this account, the contributions of the bulk conductance, surface conductance, being the current from the electric double layer, and entrance effects will be examined.
