Journal of Smooth Muscle Research
Online ISSN : 1884-8796
Print ISSN : 0916-8737
ISSN-L : 0916-8737
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The β3-Adrenoceptor-Mediated Relaxation Induced by Dopamine in Guinea Pig Taenia Caecum
Yurie AkimotoTakahiro HorinouchiYoshio TanakaKatsuo Koike
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2003 Volume 39 Issue 3 Pages 39-45

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Abstract
The mechanisms of the β-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum were examined. The relaxant response to dopamine was unaffected by propranolol (10-8 - 10-5 M) or phentolamine (10-8 - 10-5 M). Atenolol (3 × 10-7 - 3 × 10-4 M), butoxamine (10-7 - 10-4 M), prazosin (10-8 - 10-5 M), yohimbine (10-8 - 10-5 M), SCH 23390 (10-8 - 10-5 M) and haloperidol (10-8 - 10-5 M) had no effect on the potency of dopamine. The response to dopamine was antagonized in a concentration-dependent manner by bupranolol (3 × 10-6 - 3 × 10-5 M), and Schild plot of the data revealed the pA2 value of 5.55 and the slope of the regression line was 1.13. These results suggest that the relaxant response to dopamine in the guinea pig taenia caecum is mainly mediated by the β3-adrenoceptors.
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この記事はクリエイティブ・コモンズ [表示 - 非営利 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc/4.0/deed.ja
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