Journal of Smooth Muscle Research
Online ISSN : 1884-8796
Print ISSN : 0916-8737
ISSN-L : 0916-8737
Original
Spasmolytic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated uterine horns
Witness D.H. ChiwororoJohn A.O. Ojewole
Author information
JOURNALS FREE ACCESS

2009 Volume 45 Issue 1 Pages 31-38

Details
Abstract

Globally, primary dysmenorrhoea is one of the most frequent gynaecological disorders in young women. It is associated with increased uterine tone, and exaggerated contractility of uterine smooth muscles. In many rural African communities, a number of medicinal plants, including Psidium guajava Linn. (family: Myrtaceae), are used traditionally for the management, control and/or treatment of primary dysmenorrhoea. The present study was, therefore, undertaken to examine the spasmolytic effect of Psidium guajava leaf aqueous extract (PGE) on isolated, spontaneously-contracting and oestrogen-dominated, quiescent uterine horns of healthy, young adult, female Wistar rats. Graded, escalated concentrations of PGE (0.5-4.0 mg/ml) produced concentration-dependent and significant inhibitions of the amplitude of spontaneous phasic contractions of the isolated rat uterine horn preparations. In a concentration-related manner, PGE also significantly inhibited or abolished contractions produced by acetylcholine (ACh, 0.5-8.0 μg/ml), oxytocin (0.5-4.0 μU), bradykinin (2.5-10 ng/ml), carbachol (CCh, 0.5-8.0 μg/ml) or potassium chloride (K+, 10-80 mM) in quiescent uterine horn preparations isolated from the oestrogen-dominated rats. The spasmolytic effect of PGE observed in the present study lends pharmacological support to the traditional use of `guava' leaves in the management, control and/or treatment of primary dysmenorrhoea in some rural African communities.

Information related to the author

この記事はクリエイティブ・コモンズ [表示 - 非営利 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc/4.0/deed.ja
Previous article Next article
feedback
Top