INTERDIGESTIVE MIGRATING COMPLEX (IMC) AND EFFECT OF CISAPRIDE IN PATIENTSWITH NON-ULCER DYSPEPSIA (NUD)

Abstract

The 24-hr gastric and duodenal pressure measurement was performed in 5 patients with non-ulcer dyspepsia (NUD). The reduction of incidence of IMC and prolongation of the first appearance of IMC after evening meal were observed in NUD patients. The gastroprokinetic agent, cisapride 5mg, 3 times a day for 7 days significantly increased the incidence of IMC and shortened the time before the first appearance of IMC after evening meal. This result indicates that in NUDpatients impaired gastrointestinal motility is present in fasting phases and cisapride may be useful for correcting motility disorders.