EFFECT OF TERAZOSIN ON LOWER URINARY TRACT FUNCTION IN THE MALE DECEREBRATE DOG

Abstract

The effect of terazosin on the lower urinary tract function was studied by combined recording of bladder and urethral pressures and external sphincter electromyogram in 8 male decerebrate dogs. Reflex micturitions were induced by bladder filling before and after terazosin. The statistical analysis was carried out on the urodynamic parameters.
During the collecting phase, terazosin at doses of 10, 30 and 100 μg/kg produced a significant decrease in maximum urethral pressure in the dose dependent manner. Threshold pressure was significantly shown to decrease at doses of 30 and 100 μg/kg. In the urodynamic parameters of the emptying phase there was a significant decrease in maximum contraction pressure at 10 and 30 μg/kg, and in voided volume at 100 μg/kg. Terazosin seems to facilitate an initiation of the bladder contraction with a decrease in threshold pressure.
It concludes that α1 adrenergic activity seems to take an important role for the maintenance of the urethral pressure and to control the initiation of bladder contraction in modulation with threshold pressure.