Abstract
The effects of subtotal-gastrectomy (gastrectomy) on the spontaneous motility and caerulein-induced relaxation of the sphincter of Oddi (SO) were investigated in the dog. The spontaneous motility and the response to caerulein ofthe SO were recorded using perfusion method.
The basal perfusion pressure (5.1±0.5 cmH2O) and the frequency of phasic contractions (6.1±0.5 cycles/min, c/min) of the SO increased to 8.2±0.6 cmH20 (p<0.05) and 9.3±0.4c/min (p<0.05) after gastrectomy, respectively. They were observed one month after operation (7.8±0.5 cmH2O and 9.1±0.9 c/min, p<0.05), but did not change by vagotomy with sympathectomy (vagosympathectomy).
In the spontaneous motility of the SO, the motility index increased to 143.7±18.7% (p<0.05) at 4 hrs and 135.0±9.1% (p<0.05) at one month after gastrectomy, but did not increase after vagosympathectomy.
Caerulein had an inhibitory effect on the SO motility in the normal animal (48.0±4.2%). Gastrectomy reversed to the excitatory effect from theinhibitory effect to caerulein at 4 hrs (127.6±5.3%, p<0.05) and at one month (126.6±5.3%, p<0.05) after operation, but not reversed by vagosympathectomy and sham gastrectomy. The excitatory response to caerulein after gastrectomy was not effected by vagosympathectomy. It is concluded that gastrectomy induced the SO dysfunction, an increase of the perfusion pressure and the frequency of phasic contractions of the SO, and a change of the response to caerulein of the SO. Thesealterations suggests that one of the mechanisms of the regulation of the SO motility exist as the reflex from the stomach and/or uppermost duodenum through intrinsic nervous pathways.
