Abstract
To clarify the regulatory mechanism of blood flow of anodermal mucosal layers responding to the localized and transient coolong stimulation (around -4°C), we examined the change of anodermal blood flow with use of Laser Doppler Flowmeter (Periflux, Perimed). The cooling stimulation was applied to anoderm by the insertion of chilled cold stick (Poscool, Maruho) into the anus of 11 healthy male volunteer, aged 20-25 years.
Experimental results obtained are as follow;
1) The anodermal blood flow of healthy subjects are variant in degree and widely distributed from 30 to 80 Perfusion Unit (PU)
2) After cooling for five minutes by the insertion of a frozen Poscool, anodermal blood flow were increased in 8 cases out of eleven (72.7%). The changes corresponds to be 1.4 to 5.2 times.
3) Eight cases are divided into two groupes on the basis of the time course after cooling: the one is "delayed responding group" (there is a delay 10-40 minutes before the blood flow is increasing) and the other is"rapid responding group" (the blood flow is immediately increasing).
These results indicate that the anodermal blood flow, which are exposed to cooling, of healthy subjects is regulated not only by nervous mechanism but by humoral mechanism. Then, based on the Lewis reaction (cold vasodilatation), it is suggested that the short time cooling of anoderm should be appreciated as a conservative therapy of hemorrhoids and anal fissures.
