Abstract
In pulmonary circulation, small muscular resistance arteries are known to have different receptor properties and sensitivity to neurotransmitters from those of large elastic conduit arteries. It is, however, not yet certain whether the different properties are primarily due to the diameter or the location of arteries. In the present study, we compared the contractile responses to various agonists among large extralobar (ELPA, diameter: 2-3 mm), large intralobar (ILPA, diameter: 2-3 mm), and small intralobar pulmonary arteries (SPA, diameter: 300-500μm) of the rabbit.
There were no differences in normalized dose-response curves to KCl among three groups. Half maximum doses (EC50 in mM) were 38.0±2.0 (n=8, mean±SEM) in ELPA, 36.9±2.4 (n=10) in ILPA, and 39.0±0.9 (n=12) in SPA. Responses to phenylephrine, epinephrine, histamine, serotonin, and PGF2α were normalized and expressed as a relativecontraction against maximum tension to KCl. In ELPA, the contractile responses tovarious agents showed the following sequence: KCl>epinephrine>phenylephrine>serotonin>PGF2α>histamine. In ILPA and SPA, the sequence was: KCl>histamine>PGF2α>serotonin. There was little response to phenylephrine and epinephrine in ILPA and SPA.
These results demonstrate that the difference of contractile responses between ELPA and ILPA was more prominent than that between ILPA and SPA, suggesting that the location is more important than the diameter itself in determining the characteristic contractile responses of pulmonary arteries.
