The fact that the inclusion has detrimental effect to the fatigue strength of metals is well known from many experimental results, but we cannot presume the general tendency that how much decrease in the fatigue limit should be counted according to the kind and the magnitude of inclusion. It is due to not consider the characteristics of inclusion. The author, therefore, discussed the effect of inclusion in conformity with the stress state around ellipsoidal inclusions, calculated by R. H. Edwards, and stated the effect of magnitude of inclusion upon the lowering of fatigue limit. As a conclusion, it is most important to find out the contact state between the inclusion and surrounding material exactly, and if there exists the cohesion force between them, the elastic properties must be considered.