Abstract
In humans, cholesterol is derived from two main sources: diet and de novo synthesis in the liver. Cholesterol homeostasis is tightly regulated at the transcriptional, translational, and post-translational levels, and its disruption increases the risk of arteriosclerotic disease. Sterol regulatory element-binding proteins (SREBPs) regulate a wide variety of genes involved in cholesterol and fatty acid synthesis, and function as the main regulator of cholesterol homeostasis. In the present study, we analyzed the molecular mechanisms controlling the activities of SREBPs and identified several novel mechanisms. This review focuses on the latest developments in our understanding of SREBP regulation.
