Nippon Eiyo Shokuryo Gakkaishi
Online ISSN : 1883-2849
Print ISSN : 0287-3516
Original Papers
Effects of Softened Kombu Supplementation on Parameters Related to Metabolic Syndrome in Mice with Diet-induced Obesity
Azumi YamagishiHaruka KudoSeiichiro Aoe
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2015 Volume 68 Issue 3 Pages 119-128

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Abstract

We investigated the effects of dietary supplementation with softened kombu on parameters related to metabolic syndrome in mice with diet-induced obesity. C57BL/6J mice were randomly divided into three groups and fed a high-fat diet containing cellulose (CO group) , dried kombu (IN group) and softened kombu (SO group) corresponding to 5% total dietary fiber for 12 weeks. As a result, the total liver lipid content, and the serum concentrations of insulin and leptin were significantly lower in the study groups than in the CO group. Significant differences in abdominal fat mass, adipose tissue cell size and serum cholesterol concentration were observed between the SO group and the CO group. The expression of messenger RNAs (mRNAs) for hepatic fatty acid synthase (FAS) and diacylglycerol acyl transferase 1 (DGAT1) was lower in the SO group than in the CO group. These results indicate that dietary supplementation with softened kombu is more effective than dried kombu for improving parameters related to metabolic syndrome.

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© 2015 Japan Society of Nutrition and Food Science
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